Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.51 |
| ▸ | TUBB | P07437 | 2/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728244 | 0.86 | IKBKB (0.56) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL27712944 | 0.85 | MAPT (0.56) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL5728481 | 0.85 | MAPT (0.50) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL5728267 | 0.85 | ALDH1A1 (0.64) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL5727951 | 0.81 | IKBKB (0.41) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL9409696 | 0.77 | KDM4E (0.48) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL1563613 | 0.76 | GAA (1.00) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL10639081 | 0.74 | CYP1A1 (0.52) | MAPTGAAALDH1A1HPGDMEN1 | |
| SCHEMBL5727996 | 0.74 | JAK2 (0.40) | ALDH1A1HPGDALOX15IKBKBTUBB4A | |
| SCHEMBL5728140 | 0.73 | HPGD (0.42) | MAPTGAAALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2006072348-A2 | ALKINYL-SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2006-07-13 | — | — | WO | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |