Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3902781 | 1.00 | KCNA5 (0.44) | KCNA5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL3895732 | 0.92 | KCNA5 (0.35) | KCNA5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL5641569 | 0.90 | KCNA5 (0.42) | KCNA5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL3904144 | 0.90 | L3MBTL1 (0.47) | KCNA5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL3909965 | 0.90 | KCNA5 (0.42) | KCNA5KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL3902462 | 0.86 | LIMK2 (0.38) | KCNA5 | |
| SCHEMBL3903821 | 0.85 | NR1I2 (0.33) | — | |
| SCHEMBL5728253 | 0.85 | NR1I2 (0.33) | — | |
| SCHEMBL3903757 | 0.85 | L3MBTL1 (0.38) | KMT2AMEN1LMNAPOLBMAPT | |
| SCHEMBL3741654 | 0.85 | CCKBR (0.39) | KCNA5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675837-A2 | BENZO [1,2,5] THIADIAZOLE COMPOUNDS AS CCK2 MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005012275-A2 | BENZO [1, 2, 5] THIADIAZOLE COMPOUNDS AS CCK2 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-02-10 | — | — | WO | disclosed |