Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pimozide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.98 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.98 |
| ▸ | DRD3 known ✓ | P35462 | 3/20 | 0.98 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.98 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.98 |
| ▸ | HTR1A | P08908 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.98 |
| ▸ | MLNR | O43193 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | PGR | P06401 | 2/20 | 0.98 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimozide SCHEMBL14127068 | 0.99 | DRD2 (1.00) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| Pimozide SCHEMBL41584 | 0.99 | DRD2 (1.00) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| Pimozide SCHEMBL29381325 | 0.99 | DRD2 (1.00) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| SCHEMBL12863786 | 0.98 | DRD2 (0.98) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| Pimozide SCHEMBL29031811 | 0.98 | DRD2 (0.98) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| SCHEMBL10034840 | 0.94 | OPRM1 (0.91) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| Pimozide SCHEMBL14894944 | 0.93 | DRD2 (0.89) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| SCHEMBL11790943 | 0.90 | DRD2 (0.83) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| Pimozide SCHEMBL7776512 | 0.90 | OPRM1 (0.82) | DRD2KCNH2CHRM1OPRM1HTR1A | |
| SCHEMBL904856 | 0.89 | DRD2 (0.82) | DRD2KCNH2CHRM1OPRM1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646025-A1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2013-10-09 | — | — | EP | disclosed |
| EP-2600863-A2 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2013-06-12 | — | — | EP | disclosed |
| EP-2571501-A1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2013-03-27 | — | — | EP | disclosed |
| EP-2531191-A1 | SIGMA LIGANDS FOR USE IN THE PREVENTION AND/OR TREATMENT OF POSTOPERATIVE PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-12-12 | — | — | EP | disclosed |
| WO-2012072782-A1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012016980-A2 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-02-09 | — | — | WO | disclosed |
| WO-2011144721-A1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011095584-A1 | SIGMA LIGANDS FOR USE IN THE PREVENTION AND/OR TREATMENT OF POSTOPERATIVE PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-08-11 | — | — | WO | disclosed |