SCHEMBL5729113

SCHEMBL5729113

Cc1cccnc1CCBr

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.43
NOS1 P29475 1/20 0.43
NOS2 P35228 1/20 0.43
SSTR4 P31391 1/20 0.39
L3MBTL1 Q9Y468 3/20 0.36
ALDH1A1 P00352 2/20 0.36
DAO P14920 1/20 0.36
NPC1 O15118 2/20 0.36
KDM4E B2RXH2 2/20 0.36
PLAU P00749 1/20 0.36
RAB9A P51151 1/20 0.36
CYP2A6 P11509 1/20 0.36
CXCR4 P61073 2/20 0.35
HSP90AA1 P07900 1/20 0.34
MAPT P10636 1/20 0.34
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11702390 0.83
SCHEMBL29524973 0.83
Bromide SCHEMBL30250885 0.81 NOS3 (0.45) NOS3NOS1NOS2L3MBTL1ALDH1A1
Hydrochloric Acid SCHEMBL11418372 0.81 NOS3 (0.45) NOS3NOS1NOS2SSTR4L3MBTL1
SCHEMBL10245894 0.81 NOS2 (0.45) NOS3NOS1NOS2SSTR4L3MBTL1
SCHEMBL30391719 0.79 ALDH1A1 (0.45) NOS3NOS1NOS2SSTR4L3MBTL1
SCHEMBL30839509 0.79 NOS3 (0.48) NOS3NOS1NOS2SSTR4L3MBTL1
SCHEMBL4038818 0.79 ALDH1A1 (0.45) NOS3NOS1NOS2SSTR4L3MBTL1
SCHEMBL701433 0.79 NOS3 (0.48) NOS3NOS1NOS2SSTR4L3MBTL1
SCHEMBL10965334 0.79 NOS3 (0.43) NOS3NOS1NOS2SSTR4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720836-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2006-11-15 EP disclosed
WO-2005082859-A1 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2005-09-09 WO disclosed