Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 4/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131101 | 0.90 | LMNA (0.53) | LMNAJAK2HTTDRD3DRD2 | |
| SCHEMBL5729939 | 0.86 | DRD3 (0.69) | LMNAJAK2HTTDRD3DRD2 | |
| SCHEMBL5728491 | 0.84 | FNTA (0.50) | LMNAHTTDRD3DRD2CHRM2 | |
| SCHEMBL83394 | 0.74 | DRD3 (0.46) | LMNAJAK2HTTDRD3DRD2 | |
| SCHEMBL3079984 | 0.73 | DRD3 (0.51) | LMNAJAK2HTTDRD3DRD2 | |
| Hydrochloric Acid SCHEMBL5729405 | 0.73 | LMNA (0.84) | LMNAJAK2HTTDRD3DRD2 | |
| SCHEMBL6808721 | 0.71 | SETD7 (0.65) | LMNAHTTDRD3DRD2CHRM2 | |
| SCHEMBL7682349 | 0.71 | FNTA (0.53) | LMNAJAK2HTTDRD3DRD2 | |
| SCHEMBL9844279 | 0.70 | FNTA (0.54) | LMNAHTTDRD3DRD2CHRM2 | |
| Hydrochloric Acid SCHEMBL5728654 | 0.70 | DRD3 (0.61) | DRD3DRD2HTR7HTR1AFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044197-B1 | PIPERIDINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKYNE CARBOXAMIDES AS CYTOSTATIC AGENTS AND IMMUNOSUPPRESSANTS | ASTELLAS PHARMA GMBH (DE) | 2006-04-19 | — | — | EP | disclosed |
| US-6593344-B1 | These substances have especially high cytostatic activities and pronounced immunosuppressive properties which make them suitable for therapeutic treatment in broad tumor spectrum and autoimmune diseases | KLINGE PHARMA GMBH (DE) | 2003-07-15 | — | — | US | disclosed |