Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 5/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131101 | 0.87 | LMNA (0.53) | DRD3DRD2LMNAJAK2HTT | |
| SCHEMBL5729262 | 0.86 | LMNA (0.52) | DRD3DRD2LMNAJAK2HTT | |
| Hydrochloric Acid SCHEMBL5728654 | 0.84 | DRD3 (0.61) | DRD3DRD2HTR1AHTR7MAOB | |
| SCHEMBL83394 | 0.73 | DRD3 (0.46) | DRD3DRD2LMNAJAK2HTT | |
| SCHEMBL10408884 | 0.73 | SETD7 (0.66) | DRD3DRD2LMNAHTTHTR1A | |
| SCHEMBL3079984 | 0.73 | DRD3 (0.51) | DRD3DRD2LMNAJAK2HTT | |
| SCHEMBL5728491 | 0.70 | FNTA (0.50) | DRD3DRD2LMNAHTTHTR1A | |
| Hydrochloric Acid SCHEMBL5729405 | 0.70 | LMNA (0.84) | DRD3DRD2LMNAJAK2HTT | |
| SCHEMBL3440240 | 0.70 | MAOB (0.73) | DRD2HTR1AHTR2AMAOBHTR6 | |
| SCHEMBL14028451 | 0.70 | HTR1A (0.79) | DRD3DRD2HTR1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1044197-B1 | PIPERIDINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKYNE CARBOXAMIDES AS CYTOSTATIC AGENTS AND IMMUNOSUPPRESSANTS | ASTELLAS PHARMA GMBH (DE) | 2006-04-19 | — | — | EP | disclosed |
| US-6593344-B1 | These substances have especially high cytostatic activities and pronounced immunosuppressive properties which make them suitable for therapeutic treatment in broad tumor spectrum and autoimmune diseases | KLINGE PHARMA GMBH (DE) | 2003-07-15 | — | — | US | disclosed |