Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742012 | 0.90 | MEN1 (0.54) | LIMK1MEN1KMT2ACHRM4NPC1 | |
| SCHEMBL2851062 | 0.89 | PIM1 (0.55) | LIMK1MEN1KMT2ANPC1POLB | |
| SCHEMBL5739582 | 0.87 | MEN1 (0.52) | LIMK1MEN1KMT2ACHRM4NPC1 | |
| SCHEMBL5730706 | 0.87 | MEN1 (0.52) | LIMK1MEN1KMT2ACHRM4NPC1 | |
| SCHEMBL5739770 | 0.87 | MEN1 (0.52) | LIMK1MEN1KMT2ACHRM4POLB | |
| SCHEMBL5729872 | 0.87 | MEN1 (0.67) | LIMK1MEN1KMT2ACHRM4NPC1 | |
| SCHEMBL5740127 | 0.85 | MEN1 (0.50) | LIMK1MEN1KMT2ACHRM4PIM1 | |
| SCHEMBL5733057 | 0.85 | FOXM1 (0.64) | LIMK1MEN1KMT2APOLBPIM1 | |
| SCHEMBL6111088 | 0.84 | MEN1 (0.49) | LIMK1MEN1KMT2ANPC1MAPT | |
| SCHEMBL5740222 | 0.84 | MEN1 (0.48) | LIMK1MEN1KMT2ACHRM4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | claimed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | disclosed |
| EP-1619197-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1H,3H)diones and -4(3H)ones as well as Pyrido[3',2':4,5]furo[3,2-d]-pyrimidin-2,4(1H,3H)diones und -4(3H)ones as inhibitors of TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |