Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.47 |
| ▸ | IKBKB | O14920 | 3/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742012 | 0.91 | MEN1 (0.54) | MEN1KMT2AMAPTLIMK1IKBKB | |
| SCHEMBL5730706 | 0.88 | MEN1 (0.52) | MEN1KMT2AMAPTLIMK1IKBKB | |
| SCHEMBL5739582 | 0.88 | MEN1 (0.52) | MEN1KMT2AMAPTTDP1LIMK1 | |
| SCHEMBL5729872 | 0.88 | MEN1 (0.67) | MEN1KMT2AMAPTTDP1LIMK1 | |
| SCHEMBL5731048 | 0.87 | LIMK1 (0.56) | MEN1KMT2AMAPTTDP1LIMK1 | |
| SCHEMBL5740848 | 0.86 | MAPT (0.47) | MEN1KMT2AMAPTTDP1LIMK1 | |
| SCHEMBL5740127 | 0.86 | MEN1 (0.50) | MEN1KMT2AMAPTLIMK1IKBKB | |
| SCHEMBL6111088 | 0.85 | MEN1 (0.49) | MEN1KMT2AMAPTLIMK1IKBKB | |
| SCHEMBL2851062 | 0.85 | PIM1 (0.55) | MEN1KMT2AMAPTLIMK1KDM4E | |
| SCHEMBL5740222 | 0.84 | MEN1 (0.48) | MEN1KMT2AMAPTTDP1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | claimed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | claimed |
| WO-2006074919-A2 | 3-AMINO-6-ARYL(OR 6-HETEROARYL)-THIENO[2,3-B]PYRIDIN-2-CARBOXAMIDES, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME AND THEIR USE AS TNFα INHIBITORS | CURACYTE DISCOVERY GMBH (DE) | 2006-07-20 | — | — | WO | disclosed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | disclosed |