Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 5/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110379 | 0.88 | LIMK1 (0.38) | MEN1KMT2ALIMK1IKBKBKDM4E | |
| SCHEMBL5742012 | 0.87 | MEN1 (0.54) | MEN1KMT2ALIMK1IKBKBCHUK | |
| SCHEMBL5731764 | 0.86 | FOXM1 (0.47) | MEN1KMT2ALIMK1KDM4EALDH1A1 | |
| SCHEMBL5739770 | 0.84 | MEN1 (0.52) | MEN1KMT2ALIMK1IKBKBCHUK | |
| SCHEMBL5739582 | 0.84 | MEN1 (0.52) | MEN1KMT2ALIMK1IKBKBCHUK | |
| SCHEMBL5730706 | 0.84 | MEN1 (0.52) | MEN1KMT2ALIMK1IKBKBCHUK | |
| SCHEMBL5729872 | 0.84 | MEN1 (0.67) | MEN1KMT2ALIMK1IKBKBCHUK | |
| SCHEMBL5731048 | 0.84 | LIMK1 (0.56) | MEN1KMT2ALIMK1KDM4EALDH1A1 | |
| SCHEMBL5740127 | 0.83 | MEN1 (0.50) | MEN1KMT2ALIMK1IKBKBCHUK | |
| SCHEMBL2851062 | 0.82 | PIM1 (0.55) | MEN1KMT2ALIMK1KDM4EPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | claimed |
| EP-1681292-A1 | 3-Amino-6-aryl(or 6-heteroaryl)-thieno¬2,3-b|pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release | IBFB Pharma GmbH (DE) | 2006-07-19 | — | — | EP | disclosed |