Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.69 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730603 | 0.89 | LIMK1 (0.61) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL5729872 | 0.82 | MEN1 (0.67) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL4188913 | 0.81 | IKBKB (1.00) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL5731057 | 0.81 | IKBKB (0.63) | IKBKBMAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4860812 | 0.80 | IKBKB (0.83) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL5808461 | 0.80 | MAPT (0.57) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL5805727 | 0.75 | TSHR (0.47) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL5733417 | 0.74 | KMT2A (0.62) | MAPTKDM4EALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL21589904 | 0.74 | IKBKB (0.73) | IKBKBMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL5740675 | 0.74 | MEN1 (0.56) | IKBKBMAPTKDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619197-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1H,3H)diones and -4(3H)ones as well as Pyrido[3',2':4,5]furo[3,2-d]-pyrimidin-2,4(1H,3H)diones und -4(3H)ones as inhibitors of TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |