Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731488 | 0.89 | IKBKB (0.69) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL5729872 | 0.88 | MEN1 (0.67) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL5733417 | 0.84 | KMT2A (0.62) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL4194506 | 0.82 | LIMK1 (0.82) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL6217262 | 0.80 | MAPT (0.86) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL7496360 | 0.79 | MAPT (0.84) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL5740675 | 0.79 | MEN1 (0.56) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| Lithium Ion SCHEMBL7496352 | 0.78 | MAPT (0.82) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL5808461 | 0.78 | MAPT (0.57) | LIMK1MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL5742012 | 0.78 | MEN1 (0.54) | LIMK1MAPTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1619197-A1 | Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1H,3H)diones and -4(3H)ones as well as Pyrido[3',2':4,5]furo[3,2-d]-pyrimidin-2,4(1H,3H)diones und -4(3H)ones as inhibitors of TNF-alpha release | Curacyte Discovery GmbH (DE) | 2006-01-25 | — | — | EP | disclosed |