Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.63 |
| ▸ | PRKCA | P17252 | 2/20 | 0.63 |
| ▸ | BCR | P11274 | 1/20 | 0.63 |
| ▸ | SYK | P43405 | 12/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CDK2 | P24941 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464407 | 0.87 | SYK (0.59) | ABL1PRKCABCRSYKCDK2 | |
| SCHEMBL4894535 | 0.87 | SYK (0.62) | ABL1PRKCABCRSYKCDK1 | |
| Hydrochloric Acid SCHEMBL10769093 | 0.86 | SYK (0.60) | ABL1PRKCABCRSYKCDK1 | |
| SCHEMBL7471678 | 0.84 | ABL1 (0.64) | ABL1PRKCABCRSYKCDK1 | |
| SCHEMBL5734023 | 0.84 | ABL1 (0.64) | ABL1PRKCABCRSYKPRKCD | |
| SCHEMBL7460307 | 0.84 | SYK (0.55) | ABL1PRKCABCRSYK | |
| SCHEMBL4903508 | 0.84 | ABL1 (0.67) | ABL1PRKCABCRSYKEGFR | |
| SCHEMBL7476302 | 0.84 | CDK2 (0.58) | ABL1PRKCABCRSYKCDK1 | |
| SCHEMBL7469378 | 0.84 | PIK3CA (0.62) | SYKCDK2MAPTIKBKBNPC1 | |
| SCHEMBL7469928 | 0.84 | ABL1 (0.64) | ABL1PRKCABCRSYKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013120852-A1 | INTERMEDIATES FOR A NOVEL PROCESS OF PREPARING IMATINIB AND RELATED TYROSINE KINASE INHIBITORS | GRINDEKS, A JOINT STOCK COMPANY (LV) | 2013-08-22 | — | — | WO | disclosed |
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |