Centanamycin

Centanamycin

SCHEMBL5733476

COc1cc2cc(C(=O)Nc3cc(N)c4ccccc4c3CCCl)[nH]c2c(OC)c1OC

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.46
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.46
TP53 P04637 2/20 0.40
POLB P06746 2/20 0.40
MAPT P10636 2/20 0.40
HDAC1 Q13547 5/20 0.39
PLA2G7 Q13093 2/20 0.39
HDAC3 O15379 1/20 0.39
SMO Q99835 1/20 0.38
BRD4 O60885 1/20 0.38
ABCB1 P08183 1/20 0.37
CNR2 P34972 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Centanamycin SCHEMBL29441389 1.00 LMNA (0.46) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL5734847 0.93 LMNA (0.46) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL5733054 0.90 LMNA (0.47) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL6179609 0.90 LMNA (0.43) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL5734826 0.85 KDM4E (0.44) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL6178008 0.83 KDM4E (0.42) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL5733051 0.81 LMNA (0.41) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL5789593 0.80 LMNA (0.48) LMNAKDM4EALDH1A1HPGDTP53
SCHEMBL6178778 0.80 KDM4E (0.61) KDM4EALDH1A1TP53MAPTHDAC1
SCHEMBL14234930 0.78 LMNA (0.42) LMNAKDM4EALDH1A1HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115305-A1 LINKERS, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2026-04-30 US claimed
US-20260077056-A1 LINKER-PAYLOAD COMPOUND, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2026-03-19 US claimed
EP-4694935-A1 COMBINATION OF ANTIBODY-DRUG CONJUGATE AND ANTI-PD-1 ANTIBODY, AND USE THEREOF Genequantum Healthcare (Suzhou) Co., Ltd. (CN) 2026-02-18 EP claimed
EP-4688871-A1 SITE-SPEICFIC ORTHOGONAL BIOCONJUGATE MODALITY AND APPLICATION THEREOF Genequantum Healthcare (Suzhou) Co., Ltd. (CN) 2026-02-11 EP claimed
US-20260007763-A1 PEGYLATED ANTIBODY HYDROXYL-BEARING DRUG CONJUGATE SHENZHEN ENDURING BIOTECH, LTD. (CN) 2026-01-08 US claimed
US-20250387505-A1 ANTI-FGFR3 ANTIBODY CONJUGATE AND MEDICAL USE THEREOF GENEQUANTUM HEALTHCARE SUZHOU CO LTD (CN) 2025-12-25 US claimed
EP-4601702-A1 LINKER-PAYLOAD COMPOUND, CONJUGATES AND APPLICATIONS THEREOF Genequantum Healthcare (Suzhou) Co., Ltd. (CN) 2025-08-20 EP claimed
EP-4592311-A2 ANTIBODIES Lonza Ltd (CH) 2025-07-30 EP claimed
WO-2022218331-A9 LINKERS, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2025-06-19 WO claimed
US-12325755-B2 Macropinocytosing human anti-CD46 antibodies and targeted cancer therapeutics THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-06-10 US claimed
WO-2022236370-A1 IMMUNOGENIC COMPOSITION GRIFFITH UNIVERSITY (AU) 2022-11-17 WO claimed
WO-2022218331-A1 LINKERS, CONJUGATES AND APPLICATIONS THEREOF GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD. (CN) 2022-10-20 WO claimed
CN-115197297-A Linker, conjugate and application thereof 启德医药科技(苏州)有限公司 2022-10-18 CN claimed
US-11434301-B2 Anti-CD46 antibodies and methods of use THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-09-06 US claimed
US-20220202950-A1 COMPOSITIONS COMPRISING BACTERIALLY DERIVED INTACT MINICELLS FOR THERANOSTIC APPLICATIONS ENGENEIC MOLECULAR DELIVERY PTY LTD (AU) 2022-06-30 US claimed
CN-114502200-A Antibody drug conjugates 深圳康源久远生物技术有限公司 2022-05-13 CN claimed
WO-2022093729-A1 REPLICATION-DEFECTIVE VACCINES AND USES THEREOF RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2022-05-05 WO claimed
EP-1320522-B1 COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS TAIHO PHARMACEUTICAL CO LTD (JP) 2005-11-23 EP claimed
US-6660742-B2 Alkylation therapy; anticancer agent TAIHO PHARMACEUTICAL CO. LTD. (JP) 2003-12-09 US claimed
US-20030073731-A1 Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins MEDIMMUNE LIMITED (GB) 2003-04-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115305-A1 LINKERS, CONJUGATES AND APPLICATIONS THEREOF CLTB, DCLRE1A, FCGRT LMNA 517/4885KDM4E 2047/4885ALDH1A1 2425/4885
US-20260007763-A1 PEGYLATED ANTIBODY HYDROXYL-BEARING DRUG CONJUGATE PTMS, ACP1, CD2 LMNA 3725/4885KDM4E 2103/4885ALDH1A1 383/4885
US-20260077056-A1 LINKER-PAYLOAD COMPOUND, CONJUGATES AND APPLICATIONS THEREOF CLTB, LNPEP, DCLRE1A LMNA 1064/4885KDM4E 2451/4885ALDH1A1 1827/4885
US-20250387505-A1 ANTI-FGFR3 ANTIBODY CONJUGATE AND MEDICAL USE THEREOF FGFR3, IGSF11, IDUA LMNA 3483/4885KDM4E 1822/4885ALDH1A1 2376/4885
US-20030073731-A1 Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins DDB1, ERCC2, SSU72 LMNA 1231/4885KDM4E 1215/4885ALDH1A1 3356/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.