Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075784 | 0.97 | PDE4B (0.47) | PDE4BKDM4ENPC1RAB9AHPGD | |
| SCHEMBL5732452 | 0.85 | KDM4E (0.49) | PDE4BKDM4ENPC1RAB9AHPGD | |
| SCHEMBL5733680 | 0.85 | ACHE (0.40) | PDE4BKDM4ENPC1RAB9AHPGD | |
| SCHEMBL6076679 | 0.82 | KDM4E (0.49) | PDE4BKDM4ENPC1RAB9AHPGD | |
| SCHEMBL6075799 | 0.82 | ACHE (0.40) | PDE4BKDM4EHPGDALDH1A1LMNA | |
| SCHEMBL4809314 | 0.82 | TP53 (0.46) | KDM4ENPC1RAB9AHPGDMAPT | |
| SCHEMBL4805235 | 0.82 | LMNA (0.52) | PDE4BALDH1A1LMNATP53 | |
| SCHEMBL6075309 | 0.80 | MAPT (0.47) | KDM4ENPC1RAB9AHPGDMAPT | |
| SCHEMBL15659836 | 0.80 | KDM4E (0.46) | PDE4BKDM4ENPC1RAB9AHPGD | |
| SCHEMBL6075338 | 0.79 | TP53 (0.49) | NPC1RAB9AHPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505724-B2 | 4-amino substituted condensed pyrimidine compounds as PDE4 inhibitors | Grünenthal GmbH (DE) | 2016-11-29 | — | — | US | disclosed |
| US-20150353507-A1 | 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS | Grünenthal GmbH (DE) | 2015-12-10 | — | — | US | disclosed |
| EP-2951161-A1 | 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS | Grünenthal GmbH (DE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014117947-A1 | 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS | Grünenthal GmbH (DE) | 2014-08-07 | — | — | WO | disclosed |
| US-7138398-B2 | Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-21 | — | — | US | disclosed |
| EP-1131302-B1 | SUBSTITUTED 4-AMINO-2-ARYL-CYCLOPENTA [D]PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-02-01 | — | — | EP | disclosed |
| US-20040048850-A1 | Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them | AVENTIS PHARMA DEUTSCHLAND GMBH | 2004-03-11 | — | — | US | disclosed |
| US-6627628-B1 | Cardiovascular diseases such as hypertension, angina pectoris, heart failure, thrombosis and atherosclerosis. The compounds of formula (I) are able to modulate the body's own production of cyclic guanosine monophosphate (cGMP) and are suitable for | AVENTIS PHARMA DEUTSCHLAND, GMBH (DE) | 2003-09-30 | — | — | US | disclosed |
| EP-1131302-A1 | SUBSTITUTED 4-AMINO-2-ARYL-CYCLOPENTA D]PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICALREPARATIONS CONTAINING SAME | Aventis Pharma Deutschland GmbH (DE) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031047-A1 | SUBSTITUTED 4-AMINO-2-ARYL-CYCLOPENTA[D]PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICALREPARATIONS CONTAINING SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048850-A1 | Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their preparation, their use and pharmaceutical preparations comprising them | PDE3A, PDE2A, NPR1 | PDE4B 25/4885KDM4E 3302/4885NPC1 1949/4885 |
| US-20150353507-A1 | 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE12 | PDE4B 2/4885KDM4E 481/4885NPC1 3636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.