Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 16/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539646 | 0.93 | SLC6A2 (0.44) | SLC6A3SLC6A2SLC6A4P2RX7MEN1 | |
| SCHEMBL20902343 | 0.83 | SLC6A2 (0.38) | SLC6A3SLC6A2SLC6A4P2RX7 | |
| SCHEMBL5508578 | 0.81 | MEN1 (0.54) | MEN1KMT2A | |
| SCHEMBL2439001 | 0.80 | NPC1 (0.40) | POLBMEN1KMT2A | |
| SCHEMBL20902391 | 0.78 | SLC6A2 (0.40) | SLC6A3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL4249915 | 0.75 | FFAR1 (0.60) | SLC6A3SLC6A2SLC6A4P2RX7POLB | |
| SCHEMBL27482051 | 0.75 | SLC6A3 (0.37) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8467745 | 0.75 | SLC6A3 (0.64) | SLC6A3SLC6A2SLC6A4POLB | |
| SCHEMBL25333941 | 0.74 | EPHX1 (0.47) | MEN1KMT2A | |
| SCHEMBL3653836 | 0.73 | TAS1R3 (0.37) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643989-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002575-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-13 | — | — | WO | disclosed |