Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 11/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943227 | 0.89 | RORC (0.54) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL4944102 | 0.86 | MAPT (0.50) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL5738208 | 0.85 | NPSR1 (0.52) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL4939071 | 0.83 | MAPT (0.57) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL5735456 | 0.82 | REV1 (0.62) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL4942276 | 0.81 | NPSR1 (0.53) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL4940429 | 0.81 | MAPT (0.51) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL7084978 | 0.81 | MAPT (0.51) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL4945448 | 0.78 | NPSR1 (0.50) | NPSR1MAPTKDM4ELMNANPY5R | |
| SCHEMBL4939900 | 0.77 | NPY5R (0.52) | NPSR1MAPTKDM4ELMNANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | disclosed |
| EP-1268418-B1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-14 | — | — | EP | disclosed |