Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735744 | 1.00 | HTT (0.51) | HTTALDH1A1TAS1R3TAS1R1MEN1 | |
| SCHEMBL5063703 | 0.91 | TAS1R3 (0.48) | HTTTAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL5737318 | 0.90 | TAS1R3 (0.51) | HTTALDH1A1TAS1R3TAS1R1MEN1 | |
| SCHEMBL5734789 | 0.89 | TACR1 (0.49) | ALDH1A1TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL5734799 | 0.89 | TACR1 (0.49) | ALDH1A1TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL6439700 | 0.86 | CYP1A2 (0.53) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL6439699 | 0.86 | CYP1A2 (0.53) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL5733718 | 0.85 | PKM (0.57) | ALDH1A1TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL5733720 | 0.85 | PKM (0.57) | ALDH1A1TAS1R3TAS1R1MEN1KMT2A | |
| SCHEMBL5733889 | 0.85 | TACR1 (0.51) | ALDH1A1TAS1R3TAS1R1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189645-A1 | Novel 6-phenylphenantridines | ALTANA PHARMA AG (DE) | 2006-08-24 | — | — | US | disclosed |
| US-20060189641-A1 | Novel 6-phenlyphenanthridines | NYCOMED GMBH (DE) | 2006-08-24 | — | — | US | disclosed |
| EP-1658270-A1 | NOVEL 6-PHENYLPHENANTRIDINES | ALTANA Pharma AG (DE) | 2006-05-24 | — | — | EP | disclosed |
| EP-1658271-A1 | NOVEL 6-PHENYLPHENANTHRIDINES | ALTANA Pharma AG (DE) | 2006-05-24 | — | — | EP | disclosed |
| EP-1650193-A2 | 6-Phenylphenanthridines with PDE-IV inhibiting activity | ALTANA Pharma AG (DE) | 2006-04-26 | — | — | EP | disclosed |
| EP-1147089-B1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2005012253-A1 | NOVEL 6-PHENYLPHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012252-A1 | NOVEL 6-PHENYLPHENANTRIDINES | ALTANA PHARMA AG (DE) | 2005-02-10 | — | — | WO | disclosed |
| US-6476025-B1 | Phenylphennanthridines with PDE-IV inhibiting activity | ALTANA PHARMA AG (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1147089-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042020-A1 | PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189645-A1 | Novel 6-phenylphenantridines | PDE4B, PDE4A, PDE4D | HTT 4001/4885ALDH1A1 532/4885TAS1R3 632/4885 |
| US-20060189641-A1 | Novel 6-phenlyphenanthridines | PDE4A, PDE4B, PDE4C | HTT 3817/4885ALDH1A1 846/4885TAS1R3 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.