Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439700 | 1.00 | CYP1A2 (0.53) | CYP1A2POLBCYP3A4NPC1RAB9A | |
| SCHEMBL5735591 | 0.87 | PKM (0.51) | CYP1A2POLBCYP3A4NPC1RAB9A | |
| SCHEMBL5735590 | 0.87 | PKM (0.51) | CYP1A2POLBCYP3A4NPC1RAB9A | |
| SCHEMBL5735749 | 0.86 | HTT (0.51) | POLBRAB9AALDH1A1KMT2APDE4A | |
| SCHEMBL5063703 | 0.86 | TAS1R3 (0.48) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5735744 | 0.86 | HTT (0.51) | POLBRAB9AALDH1A1KMT2APDE4A | |
| SCHEMBL5734799 | 0.84 | TACR1 (0.49) | ALDH1A1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5734789 | 0.84 | TACR1 (0.49) | ALDH1A1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL5733787 | 0.84 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL5733789 | 0.84 | ALDH1A1 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147087-B1 | PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-05-11 | — | — | EP | disclosed |
| US-6538005-B2 | As inhibitors of phosphodiesterases; therapy | ALTANA PHARMA AG (DE) | 2003-03-25 | — | — | US | disclosed |
| US-20020183350-A1 | Phenanthridine-n-oxides with pde-iv inhibiting activity | GUTTERER BEATE (DE) | 2002-12-05 | — | — | US | disclosed |
| EP-1147087-A1 | PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042017-A1 | PHENANTHRIDINE-N-OXIDES WITH PDE-IV INHIBITING ACTIVITY | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183350-A1 | Phenanthridine-n-oxides with pde-iv inhibiting activity | PDE3A, PDE3B, PDE4A | CYP1A2 288/4885POLB 460/4885CYP3A4 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.