Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20526493 | 0.85 | KDM4E (0.63) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5627956 | 0.83 | SMN1; SMN2 (0.69) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3073145 | 0.83 | KDM4E (0.64) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL16735251 | 0.81 | LMNA (0.62) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL5736050 | 0.81 | POLB (0.58) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4193606 | 0.81 | TSHR (0.71) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL223559 | 0.80 | ALDH1A1 (0.71) | POLBKDM4ESMN1; SMN2TSHRMAPK1 | |
| SCHEMBL8854767 | 0.80 | ALDH1A1 (0.67) | POLBSMN1; SMN2MEN1KMT2AMAPK1 | |
| SCHEMBL12793245 | 0.79 | POLB (0.88) | POLBKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL78621 | 0.78 | POLB (0.73) | POLBKDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-6667342-B1 | Elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2003-12-23 | — | — | US | disclosed |