Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736053 | 0.81 | POLB (0.58) | POLBMEN1KMT2ATSHRPKM | |
| SCHEMBL16735251 | 0.81 | LMNA (0.62) | POLBMEN1KMT2ATSHRPKM | |
| SCHEMBL4193606 | 0.81 | TSHR (0.71) | POLBMEN1KMT2ATSHRPKM | |
| SCHEMBL12793245 | 0.79 | POLB (0.88) | POLBMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL5307467 | 0.78 | POLB (0.73) | POLBMEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL7955587 | 0.78 | POLB (0.73) | POLBMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL1459692 | 0.78 | SMN1; SMN2 (0.71) | POLBMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL29886404 | 0.78 | SMN1; SMN2 (0.67) | POLBMEN1KMT2ATSHRPKM | |
| SCHEMBL5915275 | 0.77 | POLB (0.71) | POLBMEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL20021982 | 0.76 | PKM (0.89) | POLBMEN1KMT2ATSHRPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064274-B1 | BENZENESULFONAMIDE DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| US-6667342-B1 | Elevation of pyruvate dehydrogenase activity | ASTRAZENECA AB (SE) | 2003-12-23 | — | — | US | disclosed |