Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 2/20 | 0.52 |
| ▸ | MC1R | Q01726 | 2/20 | 0.52 |
| ▸ | MC3R | P41968 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3681344 | 0.89 | POLB (0.58) | P2RX7POLBMC4RMC1RMC3R | |
| SCHEMBL3572040 | 0.82 | POLB (0.70) | P2RX7POLBMEN1KMT2AF2 | |
| SCHEMBL3577905 | 0.81 | P2RX7 (0.55) | P2RX7POLBMC4RMC1RMC3R | |
| SCHEMBL26428548 | 0.80 | DPP4 (0.52) | MEN1KMT2ADPP4F2PREP | |
| SCHEMBL3576705 | 0.80 | POLB (0.58) | P2RX7POLBMC4RMC1RMC3R | |
| SCHEMBL3573621 | 0.79 | FKBP1A (0.68) | POLBMEN1KMT2AF2ALDH1A1 | |
| SCHEMBL25592921 | 0.79 | CYP3A4 (0.66) | P2RX7POLBMEN1KMT2AF2 | |
| SCHEMBL25592977 | 0.77 | MEN1 (0.65) | P2RX7POLBMEN1KMT2AF2 | |
| SCHEMBL26425956 | 0.77 | DPP4 (0.48) | MEN1KMT2ADPP4PREPMTNR1A | |
| SCHEMBL3574503 | 0.75 | POLB (0.48) | P2RX7POLBMC4RMC1RMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-B1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-21 | — | — | EP | disclosed |
| EP-1268418-B1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS (AN) | 2006-06-14 | — | — | EP | disclosed |