SCHEMBL5738320

SCHEMBL5738320

NCc1nc2cccc(Cl)c2[nH]1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
PNMT P11086 2/20 0.38
NOS1 P29475 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
CA12 O43570 1/20 0.37
CA9 Q16790 1/20 0.37
CHEK1 O14757 1/20 0.37
FLT3 P36888 1/20 0.37
PLK3 Q9H4B4 1/20 0.37
CLK1 P49759 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7252462 0.82 LMNA (0.39) LMNANPC1RAB9ASMN1; SMN2NOS1
SCHEMBL31345698 0.82 TDP1 (0.47) LMNANPC1RAB9ASMN1; SMN2NOS1
SCHEMBL25369555 0.82 TDP1 (0.47) LMNANPC1RAB9ASMN1; SMN2NOS1
SCHEMBL1918625 0.82 DDAH1 (0.53) LMNANPC1RAB9ASMN1; SMN2NOS1
SCHEMBL5736942 0.80 RET (0.37) LMNANPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL1917495 0.79 ADORA3 (0.41) LMNANPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL10080732 0.79 CACNA1H (0.39) NPC1RAB9ASMN1; SMN2L3MBTL1CA12
SCHEMBL5738369 0.79 CACNA1H (0.36) PNMTCACNA1H
SCHEMBL11585640 0.78 MAPT (0.39) LMNANPC1RAB9ASMN1; SMN2NOS1
SCHEMBL8771674 0.78 GAA (0.58) LMNANPC1RAB9AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1176959-B1 NOVEL PROLINES AS ANTIMICROBIAL AGENTS MERCK & CO INC (US) 2006-03-08 EP disclosed
US-6579894-B2 Bactericides, fungicides MERCK & CO., INC. 2003-06-17 US disclosed
EP-1176959-A4 NOVEL PROLINES AS ANTIMICROBIAL AGENTS MERCK & CO INC (US) 2002-10-09 EP disclosed
US-6417217-B1 TREATING INFECTIONS WITH HETEROCYCLIC MICROBIOCIDES THIS INVENTION RELATES TO THE FIELD OF TRANSFER RIBONUCLEIC ACID (TRNA) SYNTHETASE INHIBITORS, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIAL ADMINISTERING TO THE SUBJECT A MERCK & CO., INC. 2002-07-09 US disclosed
EP-1176959-A1 NOVEL PROLINES AS ANTIMICROBIAL AGENTS Merck & Co., Inc. (US) 2002-02-06 EP disclosed
US-6333344-B1 ENZYME INHIBITORS AND BACTERICIDES MERCK & CO. 2001-12-25 US disclosed
WO-2000066119-A1 NOVEL PROLINES AS ANTIMICROBIAL AGENTS MERCK & CO., INC. (US) 2000-11-09 WO disclosed