Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.70 |
| ▸ | NPC1 | O15118 | 8/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.70 |
| ▸ | RELA | Q04206 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13325722 | 0.88 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL31071673 | 0.85 | NPC1 (0.67) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL13325728 | 0.84 | RAB9A (0.51) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL1691698 | 0.84 | ALDH1A1 (0.52) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL13325718 | 0.84 | NPC1 (0.63) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL31071674 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL3030499 | 0.81 | NPC1 (0.70) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL5739105 | 0.78 | RAB9A (0.68) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL22615018 | 0.75 | RAB9A (0.51) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL38665964 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401836-B1 | IMIDAZO¬1,2-A|PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS | SMITHKLINE BEECHAM CORP (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20060167252-A1 | Imidazo[1,2-a]pyridine derivatives for treatment of herpes viral infections | GUDMUNDSSON KRISTJAN | 2006-07-27 | — | — | US | disclosed |
| US-20050228004-A1 | Imidazo'1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections | SMITHKLINE BEECHAM CORPORATION | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228004-A1 | Imidazo'1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections | TPMT, IRF3, ZC3HAV1 | SMN1; SMN2 3453/4885NPC1 1119/4885RAB9A 1784/4885 |
| US-20060167252-A1 | Imidazo[1,2-a]pyridine derivatives for treatment of herpes viral infections | IRF3, IFNAR1, IL2 | SMN1; SMN2 3601/4885NPC1 1030/4885RAB9A 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.