Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1200801 | 0.72 | ALDH1A1 (0.75) | TBXA2RALDH1A1MMP9MMP13MMP2 | |
| SCHEMBL11796476 | 0.70 | MAPK1 (0.53) | TBXA2RALDH1A1MMP9MMP8MMP13 | |
| SCHEMBL16353991 | 0.70 | EGFR (0.55) | TBXA2RALDH1A1MMP9MMP8MMP13 | |
| Succinic Acid SCHEMBL19211914 | 0.69 | TSHR (0.64) | TBXA2RALDH1A1MMP9MMP8MMP13 | |
| SCHEMBL911198 | 0.69 | ALDH1A1 (0.87) | TBXA2RALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL11793418 | 0.69 | MAPK1 (0.55) | TBXA2RALDH1A1MMP9MMP8MMP13 | |
| SCHEMBL3864254 | 0.69 | TBXA2R (0.45) | TBXA2RALDH1A1 | |
| SCHEMBL3864255 | 0.69 | ALDH1A1 (0.57) | TBXA2RALDH1A1MMP9MMP8MMP13 | |
| Hydrazine SCHEMBL11854301 | 0.69 | ALDH1A1 (0.71) | TBXA2RALDH1A1MMP9MMP13MMP2 | |
| SCHEMBL5738891 | 0.69 | ALDH1A1 (0.45) | TBXA2RALDH1A1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1331937-B1 | DIBENZOXAZEPINE ALPHA V INTEGRIN RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 2006-03-15 | — | — | EP | disclosed |
| EP-1044001-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-07-06 | — | — | EP | disclosed |
| CN-1284944-A | Integrin receptor antagonists | MERCK & CO INC (US) | 2001-02-21 | — | — | CN | disclosed |
| CN-1284955-A | Integrin receptor antagonists | MERCK & CO INC (US) | 2001-02-21 | — | — | CN | disclosed |