Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459644 | 0.85 | KEAP1 (0.53) | ALDH1A1KEAP1NFE2L2HTTKMT2A | |
| SCHEMBL9188651 | 0.81 | APOBEC3G (0.50) | KEAP1NFE2L2MAPK1APOBEC3GHSD11B1 | |
| SCHEMBL8742342 | 0.81 | TDP1 (0.42) | TBXA2RALDH1A1KEAP1NFE2L2MAPK1 | |
| SCHEMBL11796476 | 0.80 | MAPK1 (0.53) | TBXA2RALDH1A1KEAP1NFE2L2MAPK1 | |
| SCHEMBL7154115 | 0.80 | SMN1; SMN2 (0.50) | ALDH1A1MAPK1HSD11B1TDP1KMT2A | |
| SCHEMBL7980856 | 0.79 | MAPK1 (0.40) | MAPK1HSD11B1TDP1KMT2A | |
| SCHEMBL11793418 | 0.79 | MAPK1 (0.55) | TBXA2RALDH1A1MAPK1HTTTDP1 | |
| SCHEMBL18837940 | 0.78 | TDP1 (0.58) | APOBEC3GHTTTDP1KMT2A | |
| SCHEMBL11797446 | 0.77 | MAPK1 (0.54) | TBXA2RALDH1A1MAPK1HTTTDP1 | |
| SCHEMBL2006245 | 0.77 | ESR1 (0.60) | KEAP1NFE2L2MAPK1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| CN-1589145-A | Alpha v integrin receptor antagonists | MERCK & CO INC (US) | 2005-03-02 | — | — | CN | disclosed |
| EP-1044001-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1007026-A4 | INTEGRIN ANTAGONISTS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1100506-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1105389-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-10-17 | — | — | EP | disclosed |
| EP-1105389-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1100506-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-05-23 | — | — | EP | disclosed |
| EP-0946165-A4 | INTEGRIN ANTAGONISTS | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000009503-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-2000006169-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0946165-A1 | INTEGRIN ANTAGONISTS | Merck & Co., Inc. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1999030713-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| WO-1999031061-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| WO-1999031099-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| WO-1998046220-A1 | COMBINATION THERAPY FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | MERCK & CO., INC. (US) | 1998-10-22 | — | — | WO | disclosed |
| WO-1998031359-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-07-23 | — | — | WO | disclosed |
| WO-1998018460-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | disclosed |