Indoline

Indoline

SCHEMBL8194348

[C].c1ccc2c(c1)CCN2

nearest known ligand 0.56

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 1/20 0.50
DRD2 P14416 1/20 0.48
DRD4 P21917 1/20 0.48
PDPK1 O15530 1/20 0.48
PARP1 P09874 1/20 0.48
PARP10 Q53GL7 1/20 0.48
PARP11 Q9NR21 1/20 0.48
ALOX15 P16050 2/20 0.46
HSD17B10 Q99714 2/20 0.46
NPC1 O15118 1/20 0.45
MAPK13 O15264 1/20 0.45
MAPK12 P53778 1/20 0.45
MAPK11 Q15759 1/20 0.45
MAPK14 Q16539 1/20 0.45
PNMT P11086 1/20 0.44
CD44 P16070 1/20 0.44
MAOB P27338 1/20 0.44
MAPT P10636 2/20 0.42
GAA P10253 5/20 0.39
MEN1 O00255 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indoline SCHEMBL29360339 0.97
Indoline SCHEMBL5629 0.97
Indoline SCHEMBL10723456 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL1085136 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL2925258 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL23295083 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL6872936 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL4903255 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL1587228 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1
Indoline SCHEMBL11401846 0.95 HTR2C (0.50) HTR2CDRD2DRD4PDPK1PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042736-A1 COMPOSITIONS AND METHODS FOR MAKING SCYTONEMIN AND ITS ANALOGS AND DERIVATIVES Board of Regents of Nevada System of Higher Education on behalf of the University of Nevada Reno (US) 2026-02-12 US disclosed
CN-111892528-B Preparation method of 7-amide indole compound 温州医科大学 2022-01-04 CN disclosed
CN-113735832-A Preparation method of 7-succinimide indole compound 温州医科大学 2021-12-03 CN disclosed
CN-111892528-A Preparation method of 7-amide indole compound 温州医科大学 2020-11-06 CN disclosed
WO-2000006582-A9 TRIMERIC AND POLYMERIC ALKALOIDS GOLDSMITH SEEDS INC (US) 2000-08-03 WO disclosed
WO-2000006582-A1 TRIMERIC AND POLYMERIC ALKALOIDS GOLDSMITH SEEDS, INC. (US) 2000-02-10 WO disclosed
US-5905148-A Photochromic spirooxazine polysiloxanes YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1999-05-18 US disclosed
US-5473068-A Photochromic spirooxazine monomers and polysiloxanes YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE (IL) 1995-12-05 US disclosed
US-5338845-A Analgesics, antiinflammatory agent STERLING WINTHROP INC. (US) 1994-08-16 US disclosed
US-5322945-A Photochromic spirooxazine monomers and polysiloxanes YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1994-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260042736-A1 COMPOSITIONS AND METHODS FOR MAKING SCYTONEMIN AND ITS ANALOGS AND DERIVATIVES TDO2, SCO2, TPH1 HTR2C 115/4885DRD2 659/4885DRD4 1606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.