Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740352 | 0.81 | KIF11 (0.65) | KIF11 | |
| SCHEMBL6207965 | 0.81 | KIF11 (0.56) | KIF11SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL6206668 | 0.80 | KIF11 (0.59) | KIF11SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL3961772 | 0.80 | KIF11 (0.67) | KIF11CYP3A4CYP2C19 | |
| SCHEMBL5899000 | 0.79 | KIF11 (0.54) | KIF11 | |
| SCHEMBL6209044 | 0.77 | KIF11 (0.57) | KIF11MAPTHPGDRXFP1 | |
| SCHEMBL4859195 | 0.77 | KIF11 (0.54) | KIF11SMN1; SMN2LMNAPDE4APDE4B | |
| SCHEMBL5739696 | 0.77 | KIF11 (0.55) | KIF11EDNRASMN1; SMN2PDE4APDE4B | |
| SCHEMBL6209290 | 0.76 | KIF11 (0.52) | KIF11SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL3905973 | 0.74 | KIF11 (0.51) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |