Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3961772 | 0.86 | KIF11 (0.67) | KIF11KIF23 | |
| SCHEMBL3962677 | 0.85 | KIF11 (0.52) | KIF11KIF23 | |
| SCHEMBL6206668 | 0.84 | KIF11 (0.59) | KIF11SMN1; SMN2KIF23 | |
| SCHEMBL6207965 | 0.84 | KIF11 (0.56) | KIF11SMN1; SMN2KIF23 | |
| SCHEMBL6209044 | 0.83 | KIF11 (0.57) | KIF11KIF23 | |
| SCHEMBL4036952 | 0.81 | KIF11 (0.76) | KIF11 | |
| Hydrochloric Acid SCHEMBL4046692 | 0.81 | KIF11 (0.75) | KIF11 | |
| Hydrochloric Acid SCHEMBL4046690 | 0.80 | KIF11 (0.74) | KIF11 | |
| SCHEMBL5739696 | 0.77 | KIF11 (0.55) | KIF11SMN1; SMN2KIF23PDE4APDE4B | |
| SCHEMBL5740356 | 0.76 | KIF11 (0.44) | KIF11SMN1; SMN2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | claimed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | claimed |
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |