Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740293 | 0.92 | MAP2K1 (0.49) | KDRMAP2K1EGFRERBB2 | |
| SCHEMBL5740887 | 0.90 | EGFR (0.50) | KDRMAP2K1EGFRERBB2 | |
| SCHEMBL5522435 | 0.87 | KDR (0.62) | KDRMAP2K1EGFRERBB2 | |
| SCHEMBL5739706 | 0.84 | KDR (0.70) | KDREGFR | |
| SCHEMBL5739638 | 0.84 | KDR (0.48) | KDRMAP2K1EGFRMEN1PABPC1 | |
| SCHEMBL5740347 | 0.83 | EGFR (0.46) | KDRMAP2K1EGFRERBB2 | |
| SCHEMBL4044547 | 0.82 | MAP2K1 (0.67) | KDRMAP2K1EGFRERBB2 | |
| SCHEMBL5516129 | 0.80 | EGFR (0.68) | KDRMAP2K1EGFRERBB2 | |
| SCHEMBL14451959 | 0.80 | KDR (0.48) | KDRMAP2K1EGFRMEN1PABPC1 | |
| SCHEMBL5740924 | 0.79 | EGFR (0.48) | KDRMAP2K1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |