Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740347 | 0.92 | EGFR (0.46) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5740887 | 0.90 | EGFR (0.50) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL4049775 | 0.86 | EGFR (0.58) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL4051995 | 0.84 | EGFR (0.58) | EGFRERBB2KDR | |
| SCHEMBL5516129 | 0.82 | EGFR (0.68) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5740293 | 0.80 | MAP2K1 (0.49) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL4225478 | 0.80 | EGFR (0.68) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL5740449 | 0.79 | KDR (0.49) | EGFRERBB2KDRMAP2K1 | |
| SCHEMBL14451959 | 0.79 | KDR (0.48) | EGFRKDRMAP2K1 | |
| SCHEMBL5739638 | 0.79 | KDR (0.48) | EGFRKDRMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183033-B1 | PYRROLOTRIAZINE INHIBITORS OF KINASES | BRISTOL MYERS SQUIBB CO (US) | 2006-03-01 | — | — | EP | claimed |