Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543788 | 0.80 | LMNA (0.41) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL4354498 | 0.77 | ALDH1A1 (0.41) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL11546547 | 0.75 | LMNA (0.51) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL18703640 | 0.74 | ALDH1A1 (0.38) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL13184169 | 0.74 | LMNA (0.55) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL11549662 | 0.74 | LRRK2 (0.46) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL16446184 | 0.74 | LMNA (0.38) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL7922166 | 0.74 | LMNA (0.41) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL18703643 | 0.71 | RECQL (0.41) | LMNAHTTALDH1A1KDM4EPOLB | |
| SCHEMBL24013956 | 0.70 | ALDH1A1 (0.34) | LMNAHTTALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751865-B2 | Dihydro-hydantoin derivatives with herbicidal activity | SYNGENTA LIMITED (GB) | 2017-09-05 | — | — | US | disclosed |
| US-9605004-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2017-03-28 | — | — | US | disclosed |
| US-20160318906-A1 | DIHYDRO-HYDANTOIN DERIVATIVES WITH HERBICIDAL ACTIVITY | SYNGENTA LIMITED (GB) | 2016-11-03 | — | — | US | disclosed |
| US-20160168126-A1 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2016-06-16 | — | — | US | disclosed |
| US-20160159819-A1 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2016-06-09 | — | — | US | disclosed |
| US-7022850-B2 | Bicyclicpyrimidones and their use to treat diseases | BRISTOL-MYERS SQUIBB CO. (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |
| US-20040242596-A1 | Bicyclicpyrimidones and their use to treat diseases | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168126-A1 | CHEMICAL COMPOUNDS | RDX, CBR3, RRS1 | LMNA 3953/4885HTT 1182/4885ALDH1A1 326/4885 |
| US-20160318906-A1 | DIHYDRO-HYDANTOIN DERIVATIVES WITH HERBICIDAL ACTIVITY | RDX, DDT, CBR3 | LMNA 3797/4885HTT 324/4885ALDH1A1 96/4885 |
| US-20160159819-A1 | CHEMICAL COMPOUNDS | RDX, CBR3, RRS1 | LMNA 3715/4885HTT 1432/4885ALDH1A1 237/4885 |
| US-20040242596-A1 | Bicyclicpyrimidones and their use to treat diseases | CCNB1, CCNB2, CCNI | LMNA 678/4885HTT 2916/4885ALDH1A1 1375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.