Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543788 | 0.75 | LMNA (0.41) | LMNAHTTKDM4EMEN1MAPT | |
| SCHEMBL5740490 | 0.74 | LMNA (0.44) | LMNAHTTKDM4EMEN1MAPT | |
| SCHEMBL11546547 | 0.71 | LMNA (0.51) | LMNAHTTKDM4EMEN1KMT2A | |
| SCHEMBL4426891 | 0.69 | GABRP (0.46) | LMNAHTTNPSR1KDM4EMEN1 | |
| SCHEMBL11549662 | 0.69 | LRRK2 (0.46) | LMNAHTTKDM4EMEN1MAPT | |
| SCHEMBL16446184 | 0.69 | LMNA (0.38) | LMNAHTTKDM4EMAPTKMT2A | |
| SCHEMBL18987920 | 0.66 | MEN1 (0.47) | LMNAHTTNPSR1KDM4EMEN1 | |
| SCHEMBL20075377 | 0.66 | ADORA2A (0.47) | LMNAHTTNPSR1KDM4EMEN1 | |
| SCHEMBL22435322 | 0.63 | LMNA (0.35) | LMNAHTTLRRK2 | |
| SCHEMBL16402408 | 0.61 | GAA (0.39) | LMNANPSR1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232271-B1 | 1-Methyl-5-alkylsulfonyl-, 1-methyl-5-alkylsulfinyl- and 1-methyl-5-alkylthio- substituted pyrazolylpyrazoles, processes for their preparation and their use as herbicides | HOECHST SCHERING AGREVO GMBH (DE) | 2001-05-15 | — | — | US | disclosed |
| EP-1034165-A1 | PYRAZOLYLPYRAZOLES SUBSTITUTED BY 1-METHYL-5- ALKYLSULPHONYL, 1-METHYL-5- ALKYLSUPHINYL AND 1-METHYL-5- ALKYLTHIO, METHODS FOR PREPARING THEM AND USE AS HERBICIDES | Aventis CropScience GmbH (DE) | 2000-09-13 | — | — | EP | disclosed |
| WO-1999026931-A1 | PYRAZOLYLPYRAZOLES SUBSTITUTED BY 1-METHYL-5- ALKYLSULPHONYL, 1-METHYL-5- ALKYLSUPHINYL AND 1-METHYL-5- ALKYLTHIO, METHODS FOR PREPARING THEM AND USE AS HERBICIDES | AVENTIS CROPSCIENCE GMBH (DE) | 1999-06-03 | — | — | WO | disclosed |
| US-5869686-A | Substituted pyrazole derivatives, processes for their preparation and their use as herbicides | HOECHST SCHERING AGREVO GMBH (DE) | 1999-02-09 | — | — | US | disclosed |
| EP-0663913-B1 | NEW SUBSTITUTED PYRAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1998-07-29 | — | — | EP | disclosed |
| US-5756424-A | POTENTIATION | HOECHST SCHERING AGREVO GMBH (DE) | 1998-05-26 | — | — | US | disclosed |
| US-5580986-A | HERBICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1996-12-03 | — | — | US | disclosed |
| EP-0663913-A1 | NEW SUBSTITUTED PYRAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994008999-A1 | NEW SUBSTITUTED PYRAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-04-28 | — | — | WO | disclosed |