Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215215 | 0.87 | RXRA (0.46) | MCL1RORC | |
| SCHEMBL215468 | 0.83 | KDM4E (0.37) | KDM4AKDM5AKDM5BMCL1OXTR | |
| SCHEMBL1645342 | 0.80 | RXRA (0.44) | KEAP1NFE2L2 | |
| SCHEMBL12361934 | 0.80 | RXRA (0.44) | KEAP1NFE2L2 | |
| SCHEMBL1644361 | 0.80 | RXRA (0.44) | KEAP1NFE2L2 | |
| SCHEMBL215462 | 0.80 | MCL1 (0.37) | EP300KDM4AKDM5AKDM5BMCL1 | |
| SCHEMBL1645226 | 0.79 | RXRA (0.43) | KEAP1NFE2L2 | |
| SCHEMBL1644379 | 0.79 | RXRA (0.43) | KEAP1NFE2L2 | |
| SCHEMBL12380765 | 0.79 | KEAP1 (0.41) | RORCKEAP1NFE2L2OXTR | |
| SCHEMBL1645078 | 0.79 | ALDH1A1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1612208-A2 | N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-01-04 | — | — | EP | disclosed |