Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 3/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743742 | 0.90 | HTR4 (0.43) | HTR4TMEM97SIGMAR1HTR3ABRD4 | |
| SCHEMBL5742835 | 0.88 | HTR4 (0.42) | HTR4TMEM97SIGMAR1HTR3ABRD4 | |
| SCHEMBL5742333 | 0.85 | HTR4 (0.40) | HTR4TMEM97SIGMAR1HTR3ABRD4 | |
| SCHEMBL5742996 | 0.85 | CCR3 (0.42) | HTR4BRD4ALDH1A1L3MBTL1CCR3 | |
| SCHEMBL3304360 | 0.77 | HTR4 (0.43) | HTR4TMEM97SIGMAR1HTR3A | |
| Hydrochloric Acid SCHEMBL3297629 | 0.76 | HTR4 (0.43) | HTR4TMEM97SIGMAR1HTR3A | |
| SCHEMBL3300553 | 0.75 | HTR4 (0.42) | HTR4TMEM97SIGMAR1HTR3AKDM4E | |
| SCHEMBL3301226 | 0.74 | FAAH (0.45) | HTR4TMEM97SIGMAR1HTR3AALDH1A1 | |
| SCHEMBL2337246 | 0.74 | DRD4 (0.51) | TMEM97SIGMAR1L3MBTL1KDM4E | |
| SCHEMBL3299666 | 0.74 | FAAH (0.45) | HTR4TMEM97SIGMAR1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903349-B1 | CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | claimed |
| EP-0903349-B1 | CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | disclosed |