Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PLD2 | O14939 | 2/20 | 0.37 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740967 | 0.85 | HTR4 (0.41) | CCR3L3MBTL1BRD4ALDH1A1HTR4 | |
| SCHEMBL18626130 | 0.76 | PLD1 (0.49) | CCR3HRH1KCNH2PLD2PLD1 | |
| SCHEMBL5743742 | 0.74 | HTR4 (0.43) | CCR3L3MBTL1BRD4ALDH1A1HTR4 | |
| SCHEMBL6582857 | 0.73 | NPSR1 (0.44) | CCR3KMT2A | |
| Hydrochloric Acid SCHEMBL7422509 | 0.72 | KDM4E (0.58) | PLD2PLD1ALDH1A1HTR4 | |
| SCHEMBL5742835 | 0.72 | HTR4 (0.42) | CCR3L3MBTL1BRD4ALDH1A1HTR4 | |
| SCHEMBL18626125 | 0.71 | HTR4 (0.45) | CCR3HRH1KCNH2PLD2PLD1 | |
| SCHEMBL2360481 | 0.70 | HTR4 (0.60) | CCR3HRH1KCNH2PLD2PLD1 | |
| SCHEMBL5742333 | 0.70 | HTR4 (0.40) | CCR3BRD4HTR4 | |
| SCHEMBL20847333 | 0.66 | HTR4 (0.43) | CCR3HRH1KCNH2PLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903349-B1 | CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | claimed |
| EP-0903349-B1 | CCR-3 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2006-01-04 | — | — | EP | disclosed |