Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 12/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 10/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.41 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740969 | 1.00 | SLC6A9 (0.54) | SLC6A9OPRM1SLC6A5OPRL1CNR2 | |
| SCHEMBL1689596 | 0.94 | SLC6A9 (0.53) | SLC6A9OPRM1SLC6A5OPRL1CNR2 | |
| SCHEMBL5363402 | 0.94 | SLC6A9 (0.53) | SLC6A9OPRM1SLC6A5OPRL1CNR2 | |
| SCHEMBL5741464 | 0.80 | SLC6A9 (0.43) | SLC6A9OPRM1SLC6A5OPRL1TSHR | |
| SCHEMBL5741465 | 0.80 | SLC6A9 (0.43) | SLC6A9OPRM1SLC6A5OPRL1TSHR | |
| SCHEMBL5741682 | 0.80 | SLC6A9 (0.43) | SLC6A9OPRM1SLC6A5OPRL1MEN1 | |
| SCHEMBL5741677 | 0.80 | SLC6A9 (0.43) | SLC6A9OPRM1SLC6A5OPRL1MEN1 | |
| SCHEMBL5363537 | 0.74 | TSHR (0.51) | SLC6A9SLC6A5CNR2TSHRALDH1A1 | |
| SCHEMBL5363541 | 0.74 | TSHR (0.51) | SLC6A9SLC6A5CNR2TSHRALDH1A1 | |
| SCHEMBL5562007 | 0.70 | SLC6A9 (1.00) | SLC6A9OPRM1SLC6A5OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594840-B1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | claimed |
| EP-1594840-B1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | disclosed |