Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363537 | 1.00 | TSHR (0.51) | TSHRMAPK1SLC6A9SLC6A5ESR1 | |
| SCHEMBL6151070 | 0.89 | HTR2A (0.43) | TSHRMAPK1SLC6A9SLC6A5ESR1 | |
| SCHEMBL6156542 | 0.89 | ESR1 (0.53) | SLC6A9SLC6A5ESR1SIGMAR1 | |
| SCHEMBL1689596 | 0.77 | SLC6A9 (0.53) | TSHRMAPK1SLC6A9SLC6A5ESR1 | |
| SCHEMBL5363402 | 0.77 | SLC6A9 (0.53) | TSHRMAPK1SLC6A9SLC6A5ESR1 | |
| SCHEMBL5371501 | 0.77 | TSHR (0.63) | TSHRMAPK1ESR1CAMK2ACAMK2G | |
| SCHEMBL7141278 | 0.75 | OPRM1 (0.60) | TSHRMAPK1ALDH1A1HTR2AHTR2C | |
| SCHEMBL6151020 | 0.75 | CAMK2A (0.43) | TSHRMAPK1ESR1CAMK2ACAMK2G | |
| SCHEMBL7141686 | 0.74 | CHRM2 (0.61) | TSHRMAPK1ALDH1A1SIGMAR1KDM4E | |
| SCHEMBL5740969 | 0.74 | SLC6A9 (0.54) | TSHRMAPK1SLC6A9SLC6A5ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176316-B2 | Amino-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-02-13 | — | — | US | claimed |
| EP-1594840-B1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | claimed |
| US-20040167166-A1 | Amino-piperidine derivatives | HOFFMANN-LA ROCHE INC. | 2004-08-26 | — | — | US | claimed |
| US-7176316-B2 | Amino-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-02-13 | — | — | US | disclosed |
| EP-1594840-B1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | disclosed |
| EP-1594840-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004072034-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-26 | — | — | WO | disclosed |
| US-20040167166-A1 | Amino-piperidine derivatives | HOFFMANN-LA ROCHE INC. | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167166-A1 | Amino-piperidine derivatives | OPRL1, GRIA1, GRIN1 | TSHR 4798/4885MAPK1 2005/4885SLC6A9 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.