SCHEMBL5741

SCHEMBL5741

COCC[C@]1(OC)CC[C@@]2(CCN(c3ccc(OC(F)(F)F)cc3)C2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 6/20 0.37
FFAR4 Q5NUL3 4/20 0.37
CHRM4 P08173 1/20 0.36
LIPE Q05469 1/20 0.36
KCNH2 Q12809 1/20 0.36
CYP3A4 P08684 3/20 0.34
CYP2C19 P33261 2/20 0.34
TSHR P16473 1/20 0.34
MEN1 O00255 1/20 0.34
USP2 O75604 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MMP3 P08254 1/20 0.34
MMP7 P09237 1/20 0.34
MMP9 P14780 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26552871 0.78 ALDH1A1 (0.47) EPHX2KCNH2ALDH1A1MMP9MMP14
SCHEMBL5019 0.77 SLC6A4 (0.49) EPHX2CHRM4LIPEKCNH2
SCHEMBL5614 0.77 LIPE (0.60) EPHX2FFAR4LIPEKCNH2CTSB
SCHEMBL1589382 0.76 LIPE (0.64) LIPE
SCHEMBL12702124 0.76 LIPE (0.64) LIPE
SCHEMBL1589383 0.76 LIPE (0.64) LIPE
SCHEMBL5301 0.74 EPHX2 (0.42) EPHX2FFAR4LIPEKCNH2
SCHEMBL24227415 0.73 USP2 (0.46) EPHX2FFAR4LIPEKCNH2CYP3A4
SCHEMBL745454 0.73 CYP1A2 (0.54) EPHX2LIPECYP3A4CYP2C19TSHR
SCHEMBL621627 0.73 DRD2 (0.52) CYP3A4CYP2C19MEN1USP2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488493-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. Hoffmann-La Roche AG (CH) 2012-08-22 EP disclosed
WO-2011045292-A1 SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2011-04-21 WO disclosed