Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9479921 | 0.79 | KDM4E (0.41) | NPC1POLBSLC2A1RAD52RAB9A | |
| SCHEMBL4767346 | 0.74 | TOP2A (0.50) | TOP2AHTR1BNPC1POLBSLC2A1 | |
| SCHEMBL4477607 | 0.73 | POLB (0.47) | NPC1POLBRAD52RAB9AKMT2A | |
| SCHEMBL7529925 | 0.71 | HTR7 (0.64) | TOP2AHTR1BLSSHRH3HTR7 | |
| SCHEMBL22837810 | 0.68 | LSS (0.50) | TOP2AHTR1BLSSHTR7HRH1 | |
| SCHEMBL29969134 | 0.68 | LSS (0.50) | TOP2AHTR1BLSSHTR7HRH1 | |
| SCHEMBL4009617 | 0.67 | PIM1 (0.37) | — | |
| SCHEMBL18949729 | 0.67 | HTT (0.56) | TOP2AHTR1BHTR7DRD3HRH1 | |
| SCHEMBL11578564 | 0.66 | HTR7 (0.62) | TOP2AHTR1BKMT2ALSSHTR7 | |
| SCHEMBL14108022 | 0.66 | HTR7 (0.57) | TOP2AHTR1BLSSHRH3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |