Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274930 | 0.81 | TSHR (0.46) | POLBKDM4EALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL23069194 | 0.79 | ALDH1A1 (0.39) | POLBRAD52RAB9AKDM4EALDH1A1 | |
| SCHEMBL23069165 | 0.75 | SCN9A (0.30) | — | |
| SCHEMBL5741306 | 0.74 | TOP2A (0.50) | TOP2AHTR1BHRH4LSSNPC1 | |
| SCHEMBL4949209 | 0.73 | ATP4A (0.45) | TOP2ANPC1POLBRAB9AHRH3 | |
| SCHEMBL7976287 | 0.73 | POLB (0.42) | NPC1POLBRAB9AKMT2AKDM4E | |
| SCHEMBL23069184 | 0.68 | NUDT1 (0.49) | POLBRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22837835 | 0.67 | LSS (0.47) | TOP2AHTR1BLSSHRH3HRH1 | |
| SCHEMBL4949283 | 0.66 | ATP4A (0.41) | NPC1POLBRAB9AKMT2AKDM4E | |
| SCHEMBL23069196 | 0.66 | ACP1 (0.36) | NPC1RAB9AKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |