Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.62 |
| ▸ | TERT | O14746 | 8/20 | 0.62 |
| ▸ | GNG2 | P59768 | 2/20 | 0.50 |
| ▸ | GNB1 | P62873 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RAC1 | P63000 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742553 | 0.86 | DOT1L (0.78) | DOT1LTERTGNG2GNB1MEN1 | |
| SCHEMBL5742129 | 0.83 | KDM4E (0.55) | DOT1LTERTKMT2AMCHR1 | |
| SCHEMBL5742713 | 0.82 | DOT1L (0.56) | DOT1LTERTGNG2GNB1MEN1 | |
| SCHEMBL5743755 | 0.81 | KDM4E (0.55) | DOT1LTERTMCHR1MAPT | |
| SCHEMBL5744288 | 0.80 | KDM4E (0.56) | DOT1LTERTMCHR1MAPTCYP1A2 | |
| SCHEMBL5742668 | 0.80 | KDM4E (0.58) | ALOX15KMT2AMAPT | |
| SCHEMBL5740513 | 0.79 | KDM4E (0.44) | DOT1LTERTMCHR1 | |
| SCHEMBL5740994 | 0.78 | PDE4D (0.47) | DOT1LMCHR1MAPT | |
| SCHEMBL5741412 | 0.77 | DOT1L (0.57) | DOT1LTERTGNG2GNB1MEN1 | |
| SCHEMBL13039513 | 0.76 | DOT1L (0.74) | DOT1LTERTGNG2GNB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |