Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.78 |
| ▸ | TERT | O14746 | 7/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | GNG2 | P59768 | 2/20 | 0.58 |
| ▸ | GNB1 | P62873 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RAC1 | P63000 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13039513 | 0.86 | DOT1L (0.74) | DOT1LTERTCYP1A2RAB9ANPC1 | |
| SCHEMBL5744090 | 0.86 | DOT1L (0.59) | DOT1LTERTCYP1A2CYP2D6RAB9A | |
| SCHEMBL5741763 | 0.86 | DOT1L (0.62) | DOT1LTERTCYP1A2CYP2D6GNG2 | |
| SCHEMBL13305664 | 0.83 | DOT1L (0.90) | DOT1LTERTGNG2GNB1MEN1 | |
| SCHEMBL5742678 | 0.83 | AGPAT2 (0.61) | DOT1LTERTCYP1A2RAB9ANPC1 | |
| SCHEMBL4074842 | 0.82 | TERT (0.91) | DOT1LTERTGNG2GNB1MEN1 | |
| SCHEMBL5741412 | 0.81 | DOT1L (0.57) | DOT1LTERTCYP1A2CYP2D6GNG2 | |
| SCHEMBL27890181 | 0.81 | TERT (0.69) | DOT1LTERTGNG2GNB1MEN1 | |
| SCHEMBL5740573 | 0.81 | DOT1L (0.57) | DOT1LTERTMAPT | |
| SCHEMBL5742405 | 0.81 | DOT1L (0.56) | DOT1LTERTCYP1A2CYP2D6GNG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |