Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.50 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741794 | 1.00 | MCHR1 (0.50) | MCHR1AGPAT2ROCK2ACP1EPHX2 | |
| SCHEMBL5743241 | 0.91 | AGPAT2 (0.53) | MCHR1AGPAT2ROCK2AURKAPDPK1 | |
| SCHEMBL5744514 | 0.91 | AGPAT2 (0.47) | MCHR1AGPAT2ROCK2ACP1AURKA | |
| SCHEMBL5740529 | 0.90 | MCHR1 (0.53) | MCHR1AGPAT2ROCK2ACP1TRPV1 | |
| SCHEMBL5740563 | 0.90 | AGPAT2 (0.52) | MCHR1AGPAT2ROCK2ACP1TRPV1 | |
| SCHEMBL5742912 | 0.89 | AGPAT2 (0.59) | AGPAT2ROCK2ACP1AURKAPDPK1 | |
| SCHEMBL5742005 | 0.89 | AGPAT2 (0.59) | AGPAT2ROCK2ACP1AURKAPDPK1 | |
| SCHEMBL5740460 | 0.88 | MCHR1 (0.50) | MCHR1AGPAT2ROCK2ACP1TRPV1 | |
| SCHEMBL5741580 | 0.88 | ACP1 (0.48) | MCHR1AGPAT2ROCK2ACP1HSD17B10 | |
| SCHEMBL5740849 | 0.86 | MCHR1 (0.51) | MCHR1AGPAT2ROCK2ACP1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |