Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
| ▸ | KDM5C | P41229 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.30 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11974548 | 0.85 | SOAT1 (0.33) | SOAT1KDM4E | |
| SCHEMBL7018212 | 0.83 | KDM4E (0.46) | SOAT1KDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL7018215 | 0.83 | KDM4E (0.46) | SOAT1KDM4EKDM6BKDM5CEGLN1 | |
| SCHEMBL19134614 | 0.79 | TSHR (0.46) | KDM4E | |
| SCHEMBL28052059 | 0.79 | MGAM (0.36) | KDM4EKDM6BKDM5CEGLN1PHF8 | |
| SCHEMBL9113394 | 0.79 | ALDH1A1 (0.35) | SOAT1 | |
| SCHEMBL28606494 | 0.79 | ALDH1A1 (0.35) | SOAT1 | |
| SCHEMBL1509789 | 0.79 | ALDH1A1 (0.35) | SOAT1 | |
| SCHEMBL8459833 | 0.74 | CES2 (0.36) | — | |
| SCHEMBL8459830 | 0.74 | CES2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644373-A1 | TRICYCLIC DELTA OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003131-A1 | TRICYCLIC DELTA OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-13 | — | — | WO | disclosed |