Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.39 |
| ▸ | HTR1A | P08908 | 10/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | HTR3A | P46098 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543078 | 0.90 | HTR1A (0.45) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C | |
| Trifluoroacetic Acid SCHEMBL5743540 | 0.81 | HTR1A (0.46) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C | |
| SCHEMBL3537519 | 0.80 | HTR1A (0.50) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C | |
| Trifluoroacetic Acid SCHEMBL5742626 | 0.80 | SLC6A2 (0.42) | SLC6A4SLC6A2HTR1ASLC6A3HTR3A | |
| SCHEMBL5742487 | 0.80 | DRD4 (0.33) | — | |
| Trifluoroacetic Acid SCHEMBL5742976 | 0.79 | HTR1A (0.44) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C | |
| Trifluoroacetic Acid SCHEMBL5744420 | 0.79 | HTR1A (0.43) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C | |
| SCHEMBL3544966 | 0.78 | SLC6A2 (0.54) | SLC6A4SLC6A2HTR1ASLC6A3HTR6 | |
| SCHEMBL3549096 | 0.78 | HTR1A (0.49) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C | |
| Trifluoroacetic Acid SCHEMBL3540434 | 0.78 | HTR1A (0.42) | SLC6A4SLC6A2HTR1ASLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |