Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543831 | 0.90 | SLC6A2 (0.54) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 | |
| Trifluoroacetic Acid SCHEMBL5742976 | 0.87 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3SLC6A9 | |
| Trifluoroacetic Acid SCHEMBL5744420 | 0.85 | HTR1A (0.43) | HTR1ASLC6A2SLC6A4SLC6A3HTR2C | |
| Trifluoroacetic Acid SCHEMBL5742485 | 0.81 | SLC6A4 (0.39) | HTR1ASLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL5743542 | 0.79 | SLC6A9 (0.39) | HTR1ASLC6A2SLC6A4SLC6A3SLC6A9 | |
| SCHEMBL3540759 | 0.78 | SLC6A2 (0.45) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 | |
| SCHEMBL3549782 | 0.78 | HTR1A (0.50) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 | |
| SCHEMBL3540654 | 0.77 | HTR1A (0.57) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 | |
| Trifluoroacetic Acid SCHEMBL3544301 | 0.76 | SLC6A2 (0.41) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 | |
| SCHEMBL3539775 | 0.76 | HTR1A (0.49) | HTR1ASLC6A2SLC6A4SLC6A3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626720-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. Lundbeck A/S (DK) | 2006-02-22 | — | — | EP | disclosed |
| WO-2004087156-A1 | 4-(2-PHENYLSULFANYL-PHENYL)-PIPERIDINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2004-10-14 | — | — | WO | disclosed |