Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691897 | 0.77 | HSD11B1 (0.40) | PREPHPGDCHRM2CHRM1CHRM3 | |
| SCHEMBL1691937 | 0.77 | HSD11B1 (0.40) | PREPHPGDCHRM2CHRM1CHRM3 | |
| SCHEMBL5938430 | 0.73 | HSD11B1 (0.46) | — | |
| SCHEMBL5939353 | 0.73 | HSD11B1 (0.46) | — | |
| SCHEMBL1692175 | 0.73 | ALDH1A1 (0.33) | — | |
| SCHEMBL3383542 | 0.71 | DDB1 (0.33) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL23406491 | 0.70 | HSD11B1 (0.41) | HPGDCHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL5938275 | 0.70 | HSD11B1 (0.41) | HPGDCHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL23406490 | 0.70 | HSD11B1 (0.41) | HPGDCHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL15245630 | 0.69 | HSD11B1 (0.42) | HPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453512-B1 | ACETYLENE DERIVATIVES HAVING MGLUR 5 ANTAGONISTIC ACTIVITY | NOVARTIS AG (CH) | 2006-05-31 | — | — | EP | claimed |