Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741166 | 0.81 | IKBKB (0.41) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL5741008 | 0.80 | USP30 (0.44) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL5741045 | 0.80 | ALOX5AP (0.42) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL7023686 | 0.79 | MEN1 (0.44) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL5743203 | 0.78 | HPGDS (0.39) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL5743013 | 0.76 | ALOX5AP (0.40) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL5741514 | 0.76 | PRMT5 (0.44) | JAK2JAK1ALOX5APFEN1HPGDS | |
| SCHEMBL5743095 | 0.76 | ALOX5AP (0.39) | ALDH1A1MEN1MAPTKMT2AJAK2 | |
| SCHEMBL4944907 | 0.73 | IKBKB (0.57) | — | |
| SCHEMBL4946551 | 0.73 | IKBKB (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |