Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BID | P55957 | 7/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.49 |
| ▸ | BAK1 | Q16611 | 6/20 | 0.49 |
| ▸ | KAT8 | Q9H7Z6 | 4/20 | 0.49 |
| ▸ | EP300 | Q09472 | 3/20 | 0.49 |
| ▸ | KAT5 | Q92993 | 3/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 3/20 | 0.43 |
| ▸ | F3 | P13726 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744962 | 0.85 | BID (0.42) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL5743029 | 0.81 | GABRA1 (0.53) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL16431334 | 0.81 | BID (0.71) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL29256460 | 0.81 | HTT (0.44) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL29256481 | 0.79 | HTT (0.43) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL5741160 | 0.79 | BID (0.55) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL678668 | 0.77 | MPO (0.50) | KDM4EHSD17B10CA12CA2CA9 | |
| Urea SCHEMBL27943935 | 0.75 | MGLL (0.47) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL9502964 | 0.75 | GABRA1 (0.57) | CA1CA2 | |
| SCHEMBL5742696 | 0.73 | SLC1A5 (0.46) | NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678146-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040133-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2005-05-06 | — | — | WO | disclosed |