Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 3/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743131 | 0.95 | BACE1 (0.50) | AGPAT2BACE1PTGS1PTGS2MAPT | |
| SCHEMBL5743563 | 0.93 | AGPAT2 (0.56) | AGPAT2BACE1PTGS1PTGS2MAPT | |
| SCHEMBL5741054 | 0.92 | BACE1 (0.46) | AGPAT2BACE1PTGS1PTGS2MAPT | |
| SCHEMBL5742375 | 0.91 | MAPT (0.51) | AGPAT2BACE1MAPTKDM4EALDH1A1 | |
| SCHEMBL5742707 | 0.89 | AGPAT2 (0.49) | AGPAT2BACE1PTGS1PTGS2MAPT | |
| SCHEMBL5744147 | 0.89 | MCHR1 (0.47) | AGPAT2BACE1PTGS1PTGS2MAPT | |
| SCHEMBL5741806 | 0.89 | BACE1 (0.47) | AGPAT2BACE1PTGS1PTGS2MAPT | |
| SCHEMBL5744066 | 0.87 | DOT1L (0.49) | AGPAT2BACE1MAPTALDH1A1OPRL1 | |
| SCHEMBL5743192 | 0.87 | AGPAT2 (0.57) | AGPAT2PTGS2MAPTKDM4EALDH1A1 | |
| SCHEMBL5740722 | 0.87 | BACE1 (0.49) | AGPAT2BACE1PTGS1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339706-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | EP | disclosed |